十大买球靠谱平台(中国)有限公司

胡磊，博士，教授，硕士研究生导师。

研究方向

动态组合化学为指导的酶抑制剂研发

酶催化生物活性分子不对称合成

高效表面活性剂研发

医药中间体合成研发

招收药物化学研究方向的学术型研究生以及生物与医药（前制药工程）专业学位研究生，欢迎具有制药工程、药学、化学、生物等相关学习背景的同学报考。

联系方式

办公室：药学楼2413室

实验室：药学楼2404室

微信：36396672

Email：leihu@ujs.edu.cn

教育背景：

2010.10至2014.10 瑞典皇家工学院 KTH-Royal Institute of Technology 有机化学博士

2007.09至2010.06 暨南大学十大买球靠谱平台 药物化学专业硕士

2003.09至2007.06 湖南师范大学 制药工程专业学士

工作经历：

2017.04至今 十大买球靠谱平台(中国)有限公司 教授

2014.12至2016.08 美国俄亥俄州立大学 The Ohio State University化学系 博士后研究员

代表性科研成果：

Wu, Y., Zhao, S., Liu, C., Hu, L.*, Development of Urease Inhibitors by Fragment-Based Dynamic Combinatorial Chemistry. ChemMedChem., 2022, e202200307.

Wu, Y., Zhao, S., Hu, L.*, Identification of Potent α-Amylase Inhibitors via Dynamic Combinatorial Chemistry. Bioorgan. Med. Chem., 2022, 55, 116609. (封面文章)

Zhao, S., Wu, Y., Hu, L.*, Identification and Synthesis of Selective Cholesterol Esterase Inhibitor using Dynamic Combinatorial Chemistry. Bioorg. Chem., 2022. 119. 105520.

Li, Y., Xu. J., Hu, L.*, Synthesis and Comparative Studies on the Surface-active and Biological

Properties of Linear Poly(glycidol) Esters. J. Mol. Liq., 2022. 360. 119538.

Han, M., Xu, J., Hu, L.*, Biocatalytic Enantioselective Construction of 1,3-Oxathiolan-5-ones via Dynamic Covalent Kinetic Resolution of Hemithioketals. Mol. Catal., 2022. 519. 112114.

Zhang, S., Li, Y., Hu, L.*, Physical and Biological Evaluation of Glucose Hydrazones as Biodegradable Emulsifiers. J. Mol. Liq., 2022. 350. 118224.

Zhang, S., Li, Y., Han, M., Wu, Y., Hu, L.*, Comparative Study of Surface-Active and Biological Properties of Lactose-derived Acylhydrazones. J. Mol. Liq., 2021. 322. 114989.

Zhao, S., Xu, J., Zhang, S., Han, M., Wu, Y., Li, Y., Hu, L.*, Multivalent Butyrylcholinesterase Inhibitor Discovered by Exploiting Dynamic Combinatorial Chemistry. Bioorg. Chem., 2021. 108. 104565.

Zhao, S., Zhang, S., Xu, J., Hu, L.*, Synthesis and Comparative Study of Emulsifying and Biological Properties of Triazolated Glucolipids. Tetrahedron, 2020, 76, 131517.

Xu, J.¹, Zhao, S.¹, Zhang, S., Hu, L.*, Development of a Multivalent Acetylcholinesterase Inhibitor via Dynamic Combinatorial Chemistry. Int. J. Biol. Macromol., 2020, 150, 1184.

Xu, J., Zhao, S., Zhang, S., Hu, L.*, Identification and Synthesis of An Efficient Multivalent E. coli Heat Labile Toxin Inhibitor - A Dynamic Combinatorial Chemistry Approach. Bioorgan. Med. Chem., 2020, 28, 115436.

Xu, J., Hu, L.*, Asymmetric One-pot Synthesis of Five- and Six-membered Lactones via Dynamic Covalent Kinetic Resolution: Exploring the Regio- and Stereoselectivities of Lipase. Tetrahedron Lett., 2019, 60, 868.

Hu, L.; Polen, S.; Hardin, A.; Pratumyot, Y.; Hadad, C.; Badjić, J. On the Transfer of Chirality, Thermodynamic Stability, and Folding Characteristics of Stereoisomeric Gated Baskets. Eur. J. Org. Chem., 2015, 31, 6832.

Hu, L.; Zhang, Y.; Ramström, O. Gelation-driven Dynamic Systemic Resolution: in situ Generation and Self-Selection of an Organogelator. Sci. Rep., 2015, 5, 11065.

Hu, L.; Ren, Y., Ramström, O. Chirality Control in Enzyme-Catalyzed Dynamic Kinetic Resolution of 1,3-Oxathiolanes. J. Org. Chem., 2015, 80, 8478.

Schaufelberger, F.; Hu, L.; Ramström, O. trans-Symmetric Dynamic Covalent Systems: Connected Transamination and Transimination Reactions. Chem. Eur. J., 2015, 21, 9776.

Hu, L.; Ramström, O. Silver-Catalyzed Dynamic Systemic Resolution of α-Iminonitriles in a 1,3-Dipolar Cycloaddition Process. Chem. Commun., 2014, 50, 3792.

Hu, L.; Zhang, Y.; Ramström, O. Lipase-Catalyzed Asymmetric Synthesis of Oxathiazin-anones through Dynamic Covalent Kinetic Resolution. Org. Biomol. Chem., 2014, 12, 3572.

Hu, L.; Schaufelberger, F.; Timmer, B. J. J.; Abellán Flos, M.; Ramström, O. Dynamic Constitutional Chemistry. In: Kirk-Othmer Encyclopedia of Chemical Technology., John Wiley & Sons, Inc., 2014. DOI: 10.1002/0471238961.consrams.a01

Hu, L.; Schaufelberger, F.; Zhang, Y.; Ramström, O. Efficient Asymmetric Synthesis of Lamivudine via Enzymatic Dynamic Kinetic Resolution. Chem. Comm. 2013, 49, 10376.

Hu, L; Lan, P; Song, Q; Huang, Z; Sun, P; Zhuo, C; Wang, Y; Xiao, S; Chen, WM. Synthesis and Antibacterial Activity of C-12 Pyrazolinyl Spiro Ketolides. Eur. J. Med. Chem., 2010, 45, 5943.

主持项目：

江苏省六大人才高峰项目 在研

医药中间体的合成工艺开发 企业委托项目 在研

江苏省自然科学基金青年项目 结题

中国博士后面上基金 结题

江苏省日常资助博士后项目 结题

江苏省双创博士项目 结题

我司高级人才启动基金 结题

主讲课程

药物化学

波谱解析（留员工）

健康科学导论（留员工）

天然药物化学（留员工）